Research
We aim to foster a community and enhance understanding of cannabis use disorder by summarizing research projects at various stages of development. Each article includes a link to the original publication for further insights, benefiting both researchers and the general public. We encourage everyone to recommend new articles in this field at any time.
23 Apr 2021
Cannabis use, abuse, and withdrawal: Cannabinergic mechanisms, clinical, and preclinical findings
Cannabis sativa is the most widely used illicit drug, primarily due to its psychoactive component, delta-9-tetrahydrocannabinol (THC). While THC has therapeutic uses, many frequent users develop cannabis use disorder (CUD), characterized by cravings, tolerance, and withdrawal symptoms. Currently, there are no effective treatments for CUD, highlighting the need for research into its neurobiological mechanisms.
Research using animal models has shed light on how cannabis affects the brain, particularly through cannabinoid type-one receptors and related intracellular signaling in the endocannabinoid system. Back-translational studies aim to connect basic and behavioral research to clinical observations, enhancing our understanding of CUD symptoms. This review summarizes significant research on the molecular, cellular, and behavioral aspects of cannabis and THC use that contribute to CUD and withdrawal.
10 Jan 2022
Clinical management of cannabis withdrawal
Cannabis withdrawal occurs in about half of regular users after abrupt cessation or significant reduction of THC-containing products, typically starting 24–48 hours later and peaking between days 2 and 6, with some symptoms lasting over three weeks. Common symptoms include anxiety, irritability, disturbed sleep, and loss of appetite, alongside less common physical symptoms like chills and headaches. Management primarily involves supportive counseling and psychoeducation, as no specific medications are approved for medically assisted withdrawal, though some treatments address short-term symptoms. Inpatient care may be necessary for individuals with significant mental health or polysubstance use issues. The significance of cannabis withdrawal lies in its potential to precipitate relapse, especially in those with concurrent disorders.